How does Pten work? Its main mode of action is to inhibit the activity of the PI3K protein, which is capable of setting off a complex biochemical cascade. In order to establish whether Pten too employs this mechanism to act on brown fat, researchers used a synthetic molecule developed at CNIO. The CNIO-PI3Ki molecule inhibits the PI3K protein in the same way as Pten and – the team confirmed – also activates brown fat.
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